Nat. Immunol: 新方法可预测I型糖尿病发作
来源:   日期:2012-11-02

  近日,国际期刊《自然—免疫学》(Nature Immunology)报道了哈佛医学院等处研究人员的成果,他们发明了一种预测I型糖尿病(T1D)发作的方法。

  T1D的研究模型采用的是非肥胖型糖尿病小鼠,但并非所有小鼠都会最终发展成末期

  Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging

  Wenxian Fu, Gregory Wojtkiewicz, Ralph Weissleder, Christophe Benoist & Diane Mathis

  All juvenile mice of the nonobese diabetic (NOD) strain develop insulitis, but there is considerable variation in their progression to diabetes. Here we used a strategy based on magnetic resonance imaging (MRI) of magnetic nanoparticles to noninvasively visualize local effects of pancreatic-islet inflammation to predict the onset of diabetes in NOD mice. MRI signals acquired during a narrow early time window allowed us to sort mice into groups that would progress to clinical disease or not and to estimate the time to diabetes development. We exploited this approach to identify previously unknown molecular and cellular elements correlated with disease protection, including the complement receptor of the immunoglobulin superfamily (CRIg), which marked a subset of macrophages associated with diabetes resistance. Administration of a fusion of CRIg and the Fc portion of immunoglobulin resulted in lower MRI signals and diabetes incidence. In addition to identifying regulators of disease progression, we show here that diabetes is set at an early age in NOD mice.